Cytolog is Misoprostol 25 mcg and 200 mcg. Misoprostol is a synthetic prostaglandin E1 analogue, which is a potent inhibitor of gastric acid secretion in humans. It also causes the cervix to soften and the uterus to contract.Prostaglandin E1 causes myometrial contractions by interacting with specific receptors on myometrial cells. This interaction results in a change in calcium concentration, thereby initiating muscle contraction. By interacting with prostaglandin receptors, misoprostol causes the cervix to soften and the uterus to contract, resulting in the expulsion of the uterine contents.Indications:Cytolog 200 mcg -First Trimester AbortioMISOPROST with mifepristone is indicated for the medical termination of intrauterine pregnancy through 49 days of pregnancy. For this purpose, pregnancy is dated from the first day of the last menstrual period in a presumed 28-day cycle with ovulation occurring at mid-cycle.Cytolog 25 mcg:Cervical Ripening ,Cervical ripening prior to uterine instrumentation- 25 mcg vaginally, every 3-4 hours until contractions; maximum six dosesCervical ripening for induction of labour in live foetus and intrauterine foetal death. Some authors suggest moistening misoprostol with 3-4 drops of saline/distilled water when used for vaginal administration.When used for cervical ripening for a pregnant woman with a live foetus, it is important that misoprostol 25 mcg should be used in institutions that are able to perform caesarean sections.Foetal well-being and uterine contractions should be monitored. Beware of uterine hyperstimulation with the risk of uterine rupture and foetal distress. Continuous monitoring of uterine contractions and foetal heart sounds should be done to rule out uterine hyperstimulation, foetal distress and meconium stained liquor.Oxytocin should not be used for 6 hours after the administration of the last dose of misoprostol as it may lead to hyperstimulation of the uterus.The risk factors for uterine rupture include later trimester pregnancies, larger doses of the drug, prior caesarean section or uterine surgery, and a history of five or more previous pregnancies. This information may allow the healthcare providers to better identify patients at risk and thereby improve the safe use of misoprostol.The patient should be examined prior to the administration of misoprostol 25 mcg. The foetus should be in vertex presentation.Multifoetal pregnancies are not excluded as long as the leading foetus is vertex.Misoprostol can be used with intact or ruptured membranes.There may be an increased risk of uterine tachysystole, uterine rupture, meconium passage, meconium staining of amniotic fluid, and caesarean delivery due to uterine hyperstimulation with the use of higher doses of misoprostol.There may be an increased risk of uterine tachysystole, uterine rupture, meconium passage, meconium staining of amniotic fluid and caesarean delivery due to uterine hyperstimulation with the use of higher doses of misoprostol.The risk of uterine rupture increases with advancing gestational ages and with prior uterine surgery, including caesarean delivery. Grand multiparity also appears to be a risk factor for uterine rupture.Gastrointestinal side effects like diarrhoea (usually dose-related and self-limiting), abdominal pain, nausea, flatulence, dyspepsia, headache, vomiting, constipation,Shivering,Hyperthermia,Dizziness. Store below 25�C